2024-생체 신장기증 이후에 수분섭취,생검,이식신장기능
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2024-생체 신장기증 이후에 수분섭취,생검,이식신장기능.pdf
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2024-생체 신장기증 이후에 수분섭취,생검,이식신장기능
Increased water intake is recommended for kidney transplant recipients; however, its efficacy
remains controversial. We hypothesized that pre-existing histological findings of the allograft might
modulate the impact of water intake. We retrospectively analyzed 167 adults with living-donor kidney
transplants (April 2011–May 2020; median observation period, 77 months) whose baseline biopsy
data were available. We compared the chronic-change group (n = 38) with the control group (n = 129)
to assess the impact of self-reported daily water intake on the estimated glomerular filtration rate
(eGFR). The range distribution of water intake was as follows: − 1000 ml (n = 4), 1000–1500 ml (n = 23),
1500–2000 ml (n = 64), 2000–2500 ml (n = 57), 2500–3000 ml (n = 16), and 3000 − ml (n = 3). Donor age
was significantly higher in the chronic-change group. In the control group, the ΔeGFR/year increase
was correlated with water intake. However, the increase in the water intake of the chronic-change
group significantly decreased ΔeGFR/year (1000–1500 ml: + 1.95 ml/min/1.73 m2
and > 2000 ml: −
1.92 ml/min/1.73 m2,
p = 0.014). This study suggested a potential influence of increased water intake
on recipients with marginal grafts in living donor kidney transplantation.
Increased water intake is recommended for kidney transplant recipients; however, its efficacy
remains controversial. We hypothesized that pre-existing histological findings of the allograft might
modulate the impact of water intake. We retrospectively analyzed 167 adults with living-donor kidney
transplants (April 2011–May 2020; median observation period, 77 months) whose baseline biopsy
data were available. We compared the chronic-change group (n = 38) with the control group (n = 129)
to assess the impact of self-reported daily water intake on the estimated glomerular filtration rate
(eGFR). The range distribution of water intake was as follows: − 1000 ml (n = 4), 1000–1500 ml (n = 23),
1500–2000 ml (n = 64), 2000–2500 ml (n = 57), 2500–3000 ml (n = 16), and 3000 − ml (n = 3). Donor age
was significantly higher in the chronic-change group. In the control group, the ΔeGFR/year increase
was correlated with water intake. However, the increase in the water intake of the chronic-change
group significantly decreased ΔeGFR/year (1000–1500 ml: + 1.95 ml/min/1.73 m2
and > 2000 ml: −
1.92 ml/min/1.73 m2,
p = 0.014). This study suggested a potential influence of increased water intake
on recipients with marginal grafts in living donor kidney transplantation.
